Kutenderera kwemascrews, Kune mhuri mbiri dzemapatya screw extruder, kusarudzwa kwezvinhu kwakakosha mukugadzirwa kwechigadzirwa chakabudirira…
Kutenderera kwemascrews kunogadzira kugovera uye kuparadzira kusanganisa.Distributive kusanganisa kunowedzera kupatsanurwa uye kubatanidzwazve kwezvinhu uku uchidzikisa simba rekuisa nekusanganisa neakaderera ekuwedzera uye planar-shear mhedzisiro.Izvi zvakafanana zvinosanganisa zvigadzirwa asi hazvinyanyi kuderedza zvakapararira particle saizi uye inopa kushoma kwekupisa uye kugera kushatisa kwezvinhu zvinonzwisisika.
Dispersive mixing inoshandisa akawedzera uye planar shear minda kutyora zvinhu zvakapararira kusvika pakukura diki, zvine mutsindo kushandisa simba kana zvishoma pamusoro pechikumbaridzo chinodiwa kuti zviputse.
Kushandiswa kwezvinhu zvakasiyana-siyana zvekusanganiswa kunobvumira twin screw extruder kuti iite zvose zvishoma kuderedza saizi uye kusanganisa kuitira kuti maAPI anogona kuiswa mupolymer mune yakapararira fomu kana, kana iyo API solubility mupolymer yakakwira zvakakwana, mune yakanyungudika fomu.Sezvo extrudate ichitonhora nekukurumidza pakubuda muextruder, chero API inonyungudika mupolymer patembiricha yekusanganiswa inogona kutadza kudzoreredza pakutonhora, zvichitungamira kune supersaturated yakasimba mhinduro.Mumamiriro ezvinhu akadaro kugadzikana kwechigadzirwa kunofanirwa kuteverwa zvakanyanya sekudzokorodzazve kweAPI pamusoro penguva refu-zvikero zvinogoneka, kunyanya pane yakakwirira tembiricha yekuchengetera uye yakakwirira API kurodha, uye inogona kukanganisa hupenyu hwesherufu yechigadzirwa chekupedzisira.
Kune mhuri mbiri dzemapatya screw extruder: yakakwirira-kumhanya simba rekuisa (HSEI) mapatya-screw extruders, ayo anonyanya kushandiswa kusanganisa, reactive kugadzirisa uye / kana devolatilization, uye yakaderera-kumhanya kunonoka fusion (LSLF) mapatya-screw extruders, yakagadzirirwa kusanganisa pakugera kwakaderera uye kupomba pakumanikidzwa kweyunifomu.Zvikururu zvinogona kunge zvichitenderedza (kuzvipukuta wega), kana kutenderedza pakaunda (karenda gap), ine maextruder mazhinji anoshandiswa kusanganisa ari kutenderedza.
Mhando dzakasiyana dzekubuda dzinofa dzinoshandiswa kugadzira iyo extrudate kune yaunoda mbiri.Izvi zvinofa zvinosanganisira shizha uye firimu rinofa rinoshandiswa mu transdermal firimu application, strand inofa inoshandiswa pakurapa tubing uye mimwe michina-eluting zvinodhaka, chimiro chinofa chinoshandiswa mukuputira, uye co-extrusion inofa inoshandiswa mudhizaini redhizaini.Yakasiyana yakadzika pasi yekubatsira zvikamu zvinoshandiswawo mukupedzisa, kusanganisira yekugezera yemvura uye mapanga emhepo ekutonhodza, mabhandi ekufambisa ekufambisa iyo extruded chigadzirwa kubva kufa kusvika kumagumo emutsara, strand-cutters yekucheka extrudate kuita tubing kana tsvimbo, uye spoolers yekuunganidza extrudate.Pelletizers anoshandiswa kucheka iyo extrudate kuita zvidimbu zvidiki kuti yakananga capsule yekuzadza uye mune yeimwe midziyo yekuumba jekiseni kuumba chigadzirwa chekupedzisira.
Sezvakaita chero fomu redosi, kusarudzwa kwezvinhu kwakakosha mukugadzirwa kwechigadzirwa chakabudirira.Kune akawanda maapplication, iyo polymer inofanirwa kunge iri thermoplastic, yakagadzikana pane tembiricha inoshandiswa mukuita, uye kemikari inoenderana neAPI panguva yekuwedzeredza.Kune akasimba emuromo dosage mafomu, mvura inonyungudika mapolymers anowanzo kusarudzwa kubva pakati pemapolima atoshandiswa mumishonga yemishonga yakadai sepoly(ethylene glycol) uye poly(vinylpyrrolidinone).Nekuwedzera kufarira kwekushandisa HME yezvigadzirwa zvemishonga, vatengesi vakuru vepolymer vari kutangawo kupa mapolymer akagadzirirwa kunyorera mishonga.Pamidziyo inobvisa zvinodhaka, mapolymers anowanzo kusanyungudika nemvura, uye ruzhinji rwezvigadzirwa zviri kugadzirwa zvinoshandisa ethylene vinyl acetate copolymers (EVAs) kana polyurethanes.
HME inobvumira iyo API kuti isanganiswe nepolymer pasi pehushoma hwekuveura uye kushushikana kwekupisa uye nekudaro nekuumbwa kwezvishoma maitiro-ane hukama neAPI zvinosvibisa.Antioxidants inowanzobatanidzwa mukati mekugadzirwa, uye nguva pfupi yekugara mubhodhoro (kazhinji pahurongwa hwemaminitsi) inobatsirawo kuderedza kupisa kwekupisa kunyanya kuenzaniswa nekusanganiswa kwebatch uye mamwe maitiro ekugadzirisa.
Imwe nzira yekudzora zvinodhaka elution kinetics kubva kune zvishandiso senge intravaginal mhete inosanganisira kuwedzera kweiyo yakapfava extrusion technique.Kuwedzeredza panguva imwe chete yemishonga-yakatakura core strand ine kusunungurwa-inodzora polymer sheath iyo inoputira musimboti mune imwechete co-extrusion process inoburitsa maviri-layer core-sheath strand.Musoro wakanyatsogadzirwa extrusion unodyiswa neaviri perpendicular extruder - imwe ichipa iyo yakakosha kuumbwa, imwe ichipa sheath zvinhu.Iyo yepakati-sheath tambo inochekwa uye migumo yakabatana kugadzira yekupedzisira mudziyo.
HME inopa vanogadzira zvigadzirwa zvezvishandiso zvekurapa, kunyungudutsa dosage mafomu uye zvinodhaka-eluting zvishandiso zvine maitiro ekuita anokwirisa API kusanganiswa nepolymer, uku ichideredza kuderedzwa kweAPI, uye kunyange kuvhura musuwo kune zvigadzirwa zvisingagone kugadzirwa nedzimwe nzira.
Nguva yekutumira: Aug-01-2017