Hot-melt extrusion (HME) inzira yakadzikwa yakashandiswa kubva kutanga kwema1930, kunyanya mukugadzira mapurasitiki…
Kune marudzi maviri e extruder: single uye twin screw extruders.Single screw extruder inonyanya kushandiswa kunyungudusa uye kuendesa mapolymers kuti aawedzere kuita anoenderera zvimiro, nepo twin screw extruder achishandiswa kunyungudutsa-kusanganisa mapolymer ane zvimwe zvinhu (pigment, fillers, reinforcers, uye APIs), uye devolatilization.Mukugadzirwa kwemishonga yekugadzira mishonga, inoda homo-geneous uye kuenderana kusanganiswa kweakawanda ekugadzira ekugadzira, mapatya screw extruder inofarirwa nekuti kutenderera kweiyo inter-meshing screws kunopa kusanganisa kuri nani kuti ibudise homogeneous solid ine yakapararira yakapararira API zvimedu, kana. yakasimba-mhinduro yeAPI mu polymer.Izvi zvinogona kuvandudza mwero wekunyungudika uye bioavail-kugona kweasina-mvura soluble API maumbirwo.Uniformly distrib-uted API zvakare inodiwa kare pakugadzirwa kwezvinodhaka-eluting zvishandiso zvine intra- uye inter-batch reproducibility yezvinodhaka-kuburitsa ki-netics.
Kunyunguduka kunoitwa nekudziya-kupisa mukati medhiramu, uye kune mapatya-screw extruders, sezvo zvigadzirwa zvichigerwa pakati pemaseru anotenderera uye pakati pema screws nemadziro ebhori sezvaanofambiswa.Iyo bhodhoro zvakare inopisa nemaheater akaiswa padhiramu, kana kunyoroveswa nemvura.Iyo tembiricha yebarrel sec-tion inowanzo gadziridzwa kuitira kuti viscosity yekunyunguduka iite yakadzikira zvakakwana kuti ibvumidze kuburitsa pasi dhiramu uye kusanganisa kwakaringana, uku uchichengeta kudziya-kudzika kwakaringana kudzivirira kupisa kwekupisa kwezvinhu.
Iyo screws ye twin screw extruder inowanzo kupa mhando dzakasiyana dzekusanganisa uye kuendesa mamiriro munzvimbo dzakasiyana mudhiramu.Munguva yekugadzirwa kwechigadzirwa, modular screws ine akawanda maeleti akaiswa pane yakajairika shaft, inobvumira kusona uye optimization yeiyo screw dhizaini yechigadzirwa chimwe nechimwe.Zvikamu zve screw zvinogona kugadzirwa kuita particle size kuderedza, kusanganisa uye kufambisa mabasa.Kureba kwe screw inoenderana nedhayamita yedhiramu (iyo L/D reshiyo) inosarudzwa kuti ikwidze dhigirii rekusanganisa uye huwandu hwenzvimbo dzinodiwa kuti uwane yekupedzisira chigadzirwa char-acteristics.Muenzaniso weiyo yakazara modular screw.Single-chidimbu kugadzira screws inogona kuvakwa kune imwechete dhizaini seyakagadzirwa screws, asi iri nyore kuchenesa kuti cGMP itevedzere.
Nguva yekutumira: Jun-03-2017